| 翻訳と辞書 |
| LINC complex ： ウィキペディア英語版 |
LINC complex
The LINC-complex (Linker of Nucleoskeleton and Cytoskeleton) is a protein complex associated with both inner and outer membranes of the nucleus. It is composed of SUN-domain proteins and KASH-domain proteins. The SUN-domain proteins are associated with both nuclear lamins and chromatin and cross the inner nuclear membrane. They interact with the KASH-domain proteins in the perinuclear (lumen) space between the two membranes. The KASH domain proteins cross the outer nuclear membrane and interact with actin filaments, microtubule filaments (through dynein and kinesin motors), intermediate filaments (through spectrin), centrosomes and cytoplasmic organelles.
The number of SUN-domain and KASH-domain proteins increased in evolution.〔Crisp et al. (2005) "Coupling of the nucleus and cytoplasm: role of the LINC complex" Journal of Cell Biology 172,41-53 PMID 16380439〕
==Function==
The function of the LINC complex appears to be in many cell activities. These include nuclear relocation/movement, moving meiotic chromosomes to find their homologues at leptotene/zygotene, attaching the centrosome to the outer nuclear membrane and responding to extracellular mechanical stimuli.〔Tapley and Starr (2013) "Connecting the nucleus to the cytoskeleton by SUN-KASH bridges across the nuclear envelope" Current Opinions in Cell Biology,57-62 PMID 23149102〕 LINC complex, by virtue of providing internal cell connectivity, is required for sensing of various mechanical stimuli including high frequency vibrations.〔Uzer et al.(2015) "Cell mechanosensitivity to extremely low magnitude signals is enabled by a LINCed nucleus" Stem Cells,doi: 10.1002/stem.2004 PMID 25787126〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
■ウィキペディアで「LINC complex」の詳細全文を読む
スポンサード リンク
| 翻訳と辞書 : 翻訳のためのインターネットリソース |
Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.
|
|